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US 9,850,466 B2Granted
Somatic cells with innate potential for pluripotency
AssigneeThe Regents of the University of California
InventorThea D. Tlsty
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Abstract
Aspects of the present invention are drawn to compositions of somatic cells with innate potential for pluripotency (SCIPP). SCIPP have the capacity to differentiate into functional derivatives of each of the major germ layers (i.e., ectodermal, endodermal and mesodermal). Also provided are methods and kits for identifying and isolating the somatic cells from a subject as well as for employing SCIPP for research or therapeutic purposes.
Claims14
An isolated population of cells,
- wherein at least 8% of the cells are Somatic Cells with an Innate Potential for Pluripotency (SCIPP),
- wherein the SCIPP are CD73+/CD90−/CD45− cells, wherein CD45 is a Lineage marker, and
- wherein the SCIPP cells are bound by an anti-CD73 antibody,
- wherein the anti-CD73 antibody is immobilized on a solid support or is conjugated to a detectable label.
1 more element
An isolated population of cells,
- wherein at least 8% of the cells are Somatic Cells with an Innate Potential for Pluripotency (SCIPP),
- wherein the genetically modified SCIPP are CD73+/CD90−/CD45− cells, wherein CD45 is a Lineage marker, and
- wherein the SCIPP cells are genetically modified.
Dependencies are inferred from the claim text.