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US 9,850,464 B2Granted
Method for the detection of polypeptide specific immune cells
AssigneeLophius Biosciences GmbH
InventorsSascha Barabas, Katrin Edmaier-Schröger, Ludwig Deml
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Abstract
The present invention relates to a method for polypeptide transfer into cells. The present invention further relates to the detection of polypeptide-specific immune cells and the priming, expansion and reactivation of polypeptide-specific T cells. Moreover the present invention relates to polypeptides of the methods of the present invention in combination with urea and their use for research, diagnosis or treatment and prevention of diseases in animals and humans.
Claims22
A method for priming, expansion and/or reactivation of polypeptide-specific T cells comprising the following steps:
- a) incubating polypeptides in a solution comprising cyanate ions, wherein the cyanate ions are present at a concentration in the range from about 1 to about 1000 mmol/l, and
- b) incubating cells with the polypeptides of step a) in the presence of urea and in absence or presence of immune-modulatory substances.
Dependencies are inferred from the claim text.