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US 9,850,341 B2Granted
Method for preparing polymer microparticles by spray process
AssigneeVaim Co., Ltd.
InventorGun Poong Kim
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Abstract
The present invention relates to a method for preparing polymer microparticles by a spray process, wherein a polymer solution obtained by dissolving a polyester-based polymer in ethylene carbonate (hereinafter, referred to as “EC”), which is a solvent, is sprayed at a low temperature hydrocarbon or alcohol solution, thereby preparing frozen EC/polymer microparticles, the frozen EC/polymer microparticles are dissolved in a salt aqueous solution, thereby dissolving and removing EC, and the residual EC in water is removed by washing.
Claims4
A method for preparing biodegradable polymer microparticles, comprising:
- dissolving a biodegradable polyester polymer in ethylene carbonate (EC) to obtain a polymer/EC solution;
- spraying the polymer/EC solution onto an alcohol selected from the group consisting of methanol or ethanol or an aqueous solution thereof where the alcohol has a temperature between −20° C. and 0° C., thus obtaining frozen polymer/EC microparticles;
- dissolving and removing EC from the polymer/EC microparticles by adding the polymer/EC microparticles into a salt aqueous solution;
- and
- filtering and washing the microparticles with water so as to eliminate the remaining EC, thus obtaining biodegradable polymer microparticles.
2 more elements
Dependencies are inferred from the claim text.