Water soluble nitric oxide-releasing polyglucosamines and uses thereof

A polyglucosamine comprising,

• at least one structural unit:
• wherein,
• Q is —(CRcRd)v—;
• wherein Rc and Rd, in each instance, are independently hydrogen or C1-5 alkyl;
• and v is an integer from 2 to 6;
• p is an integer from 1 to 10;
• A is
• wherein, L is S, O or N;
• and
• G, in each instance, is independently, hydrogen, or is taken together with
• L to form a nitric oxide donor or is absent;
• X is hydrogen, C1-5 alkyl or is taken together with N to form a nitric oxide donor;
• B is absent or is selected from the group consisting of hydrogen, hydroxyl, C1-5 alkyl, or —Y—Z, wherein Y is a spacer and Z is a polymer or a terminus;
• wherein the polyglucosamine comprises at least one nitric oxide donor selected from the group consisting of a diazeniumdiolate, nitrosothiol, a nitrosamine, a hydroxyl nitrosamine, a hydroxyl amine, a hydroxyurea, and combination thereof;
• and
• wherein G is taken together with L to form the at least one nitric oxide donor or X is taken together with N to form the at least one nitric oxide donor.