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US 9,850,313 B2Granted
Cancer biomarkers and methods of use thereof
AssigneeBoard of Regents of the University of Nebraska
InventorsVimla Band, Hamid Band, Sameer Mirza
Life of this patent
Estimating the term…
Abstract
Methods and compositions for treating cancer, particularly breast cancer, are disclosed.
Claims12
A method for treating breast cancer in a subject, said method comprising:
- a) determining the cellular localization of alteration/deficiency in activation-3 (ADA3) in a biological sample obtained from said subject, wherein said biological sample is a breast cancer tissue sample;
- and
- b) administering hormonal therapy to said subject when ADA3 is determined to be predominantly nuclear and administering human epidermal growth factor receptor 2 (HER2) targeted therapy when ADA3 is determined to be predominantly cytoplasmic or overexpressed, thereby treating the breast cancer in said subject.
A method for treating breast cancer in a subject, said method comprising:
- a) determining the cellular localization of alteration/deficiency in activation-3 (ADA3) in a biological sample obtained from said subject, wherein said biological sample is a breast cancer tissue sample;
- and
- b) administering hormonal therapy to said subject when ADA3 is determined to be predominantly nuclear, thereby treating the breast cancer in said subject.
Dependencies are inferred from the claim text.