Anti-TROP2 antibody-drug conjugate

An antibody-drug conjugate, wherein a linker and an antitumor compound represented by the following formula and anti-TROP2 antibody are connected:

• -(Succinimid-3-yl-N)—CH2CH2CH2CH2CH2—C(═O)-GGFG-NH—CH2—O—CH2—C(═O)—(NH-DX)
• wherein
• -(Succinimid-3-yl-N)— has a structure represented by the following formula:
• which is connected to the antibody at position 3 thereof and is connected to a methylene group in the linker structure containing this structure on the nitrogen atom at position 1, and (NH-DX) represents a group represented by the following formula:
• wherein the nitrogen atom of the amino group at position 1 is the connecting position, wherein the anti-TROP2 antibody comprises CDRH1 consisting of the amino acid sequence of SEQ ID NO:
• 23, CDRH2 consisting of the amino acid sequence of SEQ ID NO:
• 24 and CDRH3 consisting of the amino acid sequence of SEQ ID NO:
• 25 in its heavy chain variable region and CDRL1 consisting of the amino acid sequence of SEQ ID NO:
• 26, CDRL2 consisting of the amino acid sequence of SEQ ID NO:
• 27 and CDRL3 consisting of the amino acid sequence of SEQ ID NO:
• 28 in its light chain variable region.