Compositions and methods for diagnosing and treating cancer
AssigneeOncoMed Pharmaceuticals, Inc.
InventorsAustin Gurney, John Lewicki, Sanjeev Satyal, Timothy Hoey
Life of this patent
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Abstract
An isolated antibody that specifically binds to an extracellular domain of two or more human FZD receptors and inhibits growth of tumor cells is described. Also described is a method of treating cancer comprising administering an antibody of the present disclosure in an amount effective to inhibit tumor cell growth.
Claims11
An isolated monoclonal antibody that comprises an antigen binding site that specifically binds to the extracellular domains of human FZD5 and FZD8, wherein the extracellular domain of human FZD5 comprises approximately amino acid 27 to 233 of SEQ ID NO:3, and the extracellular domain of human FZD8 comprises approximately amino acid 28 to 158 of SEQ ID NO:6.
The isolated monoclonal antibody of claim wherein the antigen binding site binds to the extracellular domains of human FZD5 and FZD8 at a site comprising amino acid residues that are identical between the extracellular domains of human FZD5 and FZD8.
Dependencies are inferred from the claim text.