US 9,850,309 B2 · Medicament comprising activity modulator for CD300a-expressing cell associated with allergic disease, CD300a gene-deficient mouse, and use of activity modulator for CD300a-expressing cell

Abstract

The present invention provides medicaments for allergic diseases (atopic dermatitis, asthma, and the like), and a tool useful for pathology analysis of allergic diseases. A medicament containing as an effective component an activity modulator for suppressing inhibitory signal transduction of a CD300a-expressing myeloid cell, which activity modulator contains a substance that inhibits binding of CD300a to phosphatidyl serine, can be used for treatment or prophylaxis of an allergic disease. A CD300a gene-deficient mouse can be used as a model mouse in which the allergic disease is hardly induced after administration of a substance that induces the allergic disease, which may be used for carrying out pathology analysis of an allergic disease, or for screening of a possible candidate substance for an effective component of a therapeutic agent or prophylactic agent for the disease.

Claims4

Dependent claims

A method of treatment or prophylaxis of an allergic disease, the method comprising:

administering an effective amount of an activity modulator for suppressing inhibitory signal transduction of a CD300a-expressing myeloid cell to a human, said activity modulator comprising a substance that inhibits binding of CD300a to phosphatidyl serine, which substance is an anti-human CD300a antibody comprising:
an H-chain variable region having the amino acid sequence of SEQ ID NO:3 or an amino acid sequence that is the same as the amino acid sequence of SEQ ID NO:3 except that 1, 2, 3, 4, or 5 amino acid(s) is/are substituted in one or more regions other than in a complementarity determining region;
and
an L-chain variable region having the amino acid sequence of SEQ ID NO:4 or an amino acid sequence that is the same as the amino acid sequence of SEQ ID NO:4 except that 1, 2, 3, 4, or 5 amino acid(s) is/are substituted in one or more regions other than in a complementarity determining region.

1 more element

Dependencies are inferred from the claim text.

Medicament comprising activity modulator for CD300a-expressing cell associated with allergic disease, CD300a gene-deficient mouse, and use of activity modulator for CD300a-expressing cell

Life of this patent

Medicament comprising activity modulator for CD300a-expressing cell associated with allergic disease, CD300a gene-deficient mouse, and use of activity modulator for CD300a-expressing cell

Life of this patent

Abstract

Claims4