Methods of modulating immunity
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsHoward Weiner, Mohamed H. Sayegh
Life of this patent
Estimating the term…
Abstract
The invention provides novel methods of administering anti-CD3 antibodies, e.g., via oral or mucosal delivery. The invention also provides methods of treating, preventing, or delaying the onset of autoimmune disorders by oral or mucosal administration of anti-CD3 antibodies. Finally, the invention provides compositions including anti-CD3 antibodies, suitable for oral or mucosal administration.
Claims10
A method of treating an autoimmune disease in a subject, wherein the disease is selected from the group consisting of multiple sclerosis and rheumatoid arthritis, the method comprising administering to the subject an F(ab')2 antibody fragment of an anti-CD3 antibody, wherein the administering is nasal.
Dependencies are inferred from the claim text.