Antibodies that recognize IAPP
AssigneeProthena Biosciences Limited
InventorsRobin Barbour, Yue Liu
Life of this patent
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Abstract
The invention provides monoclonal antibody 6B8 and related antibodies. The 6B8 antibody binds to an epitope within residues 3-12 of IAPP. The antibodies of the invention are useful, for example, for treating disorders associated with IAPP accumulation, particularly accumulation of IAPP deposits. Such disorders include type 2 diabetes, metabolic syndrome, impaired insulin tolerance, impaired glucose tolerance, insulinomas, and related conditions.
Claims14
An isolated monoclonal antibody that binds to human IAPP comprising 3 heavy chain CDRs (CDR1, CDR2 and CDR3) of SEQ ID NO:9 and 3 light chain CDRs (CDR1, CDR2 and CDR3) of SEQ ID NO:20.
An isolated antibody comprising a mature heavy chain variable region comprising CDRs 1, 2 and 3 having sequences of SEQ ID NOS:
- 10, 11 and 12 respectively, the mature heavy chain variable region having an amino acid sequence at least 90% identical to H2 (SEQ ID NO:
- 17) and a mature light chain variable region comprising CDRs 1, 2 and 3 having sequences of SEQ ID NOS:21, 22 and 23 respectively, the mature light chain variable region having an amino acid sequence at least 90% identical to L1 (SEQ ID NO:26), wherein the antibody specifically binds to human IAPP.
Dependencies are inferred from the claim text.