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US 9,850,298 B2Granted
Methods for treating ulcers in thalassemia syndrome with an ActRIIB polypeptide
AssigneeAcceleron Pharma Inc.
InventorKenneth M. Attie
Life of this patent
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Abstract
The present disclosure provides compositions and methods for treating or preventing ulcers in subjects having low red blood cell levels and/or hemoglobin levels (e.g, anemia). In some embodiments, the compositions of the disclosure may be used to treat or prevent ulcers associated with anemia.
Claims26
A method for treating a cutaneous ulcer in a subject that has thalassemia syndrome, comprising administering to the subject a polypeptide comprising an amino acid sequence that is at least 85% identical to the sequence of amino acids 29-109 of SEQ ID NO:
- 1, wherein the polypeptide comprises and acidic amino acid at the position corresponding to position 79 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.