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US 9,850,297 B2Granted
Secreted frizzle-related protein 5 (SFRP5) binding proteins
AssigneeAmgen Inc.
InventorsJiangwen Majeti, YuMei Xiong, Wen-Chen Yeh, Alykhan S. Motani, Yang Li
Life of this patent
Estimating the term…
Abstract
Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the SFRP5 polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia elevated glucose levels, elevated insulin levels and diabetic nephropathy.
Claims11
An antigen binding protein that specifically binds SFRP5 (secreted frizzled-related protein5) and comprises:
- i. a CDRH1 of SEQ ID NO:23;
- ii. a CDRH2 of SEQ ID NO:24;
- iii. a CDRH3 of SEQ ID NO:25;
- i. a CDRL1 of SEQ ID NO:26;
- ii. a CDRL2 of SEQ ID NO:27;
- and
- iii. a CDRL3 of SEQ ID NO:28.
4 more elements
Dependencies are inferred from the claim text.