Compositions which regulate the epithelial brush border Na+/H+ exchanger NHE3 and their methods of use in gastrointestinal disease
AssigneesThe Johns Hopkins University, The Penn State Research Foundation
InventorsMark Donowitz, Nicholas Constantine Zachos, Damian Brett Van Rossum, Randen Patterson
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Abstract
A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided.
Claims15
A sodium/hydrogen Exchanger 3 (NHE3) Inhibitory Regulatory Complex ICRX Competing Peptide (ICRX-CP), or a functional portion or analog or derivative thereof.
A peptide comprising the amino acid sequence of SEQ ID NO:
- 1, or a functional portion or analog or derivative thereof.
Dependencies are inferred from the claim text.