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US 9,850,286 B2Granted
Cytokine
AssigneeLondon School of Hygiene and Tropical Medicine
InventorsUrsula Gompels, David Dewin, Julie Catusse
Life of this patent
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Abstract
A novel cytokine, U83A, is described, as are variant forms of the cytokine, having a wide range of agonistic and antagonistic activity against chemokine receptors. Uses of the chemokine in treatment of a range of diseases, including cancers and HIV/AIDS, are described.
Claims15
An expression vector comprising:
- (a) a polynucleotide encoding the polypeptide of SEQ ID NO:5 or SEQ ID NO:6;
- (b) a polynucleotide complementary to the polynucleotide of (a);
- (c) a polynucleotide that hybridizes to the poly nuoleotide of (b) and encodes a polypeptide that functions as an agonist of at least one cytokine receptor, wherein the at least one cytokine receptor is a cytokine receptor that is activated by the polypeptide of SEQ ID NO:5 or SEQ ID NO:6;
- or
- (d) a polynucleotide that hybridizes to the complement of a polynucleotide encoding the polypeptide of SEQ ID NO:7 or SEQ ID NO:8 and encodes a polypeptide that functions as an antagonist of at least one cytokine receptor, wherein the at least one cytokine receptor is a cytokine receptor that is inhibited by the polypeptide of SEQ ID NO:7 or SEQ ID NO:8,
- wherein hybridization occurs at 65° C. and the polynucleotides remain hybridized after washing with 0.2×SSC.
3 more elements
Dependencies are inferred from the claim text.