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US 9,850,280 B2Granted
Melanocortin receptor ligands
AssigneeIpsen Pharma S.A.S.
InventorsZheng Xin Dong, Jacques-Pierre Moreau
Life of this patent
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Abstract
The present invention is directed to compounds according to formula, (R2R3)-A1-c(A2-A3-A4-A5-A6-A7-A8-A9)-A10-R1, and pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
Claims9
A compound selected from the group consisting of:
- D-Phe-c(Cys-His-D-(Et)Tyr-Arg-Trp-β-Ala-D-Cys)-Thr-NH2 (SEQ ID NO:24);
- D-Phe-c(Cys-His-D-Phe-Arg-Trp-β-Ala-D-Cys)-Thr-NH2 (SEQ ID NO:3);
- D-Phe-c(Cys-His-D-Phe-Arg-Trp-Gaba-D-Cys)-Thr-NH2 (SEQ ID NO:3);
- D-Phe-c(Cys-His-D-Phe-hArg-Trp-β-Ala-D-Cys)-Thr-NH2 (SEQ ID NO:23);
- D-Phe-c(Cys-His-D-(Et)Tyr-hArg-Trp-β-Ala-D-Cys)-Thr-NH2 (SEQ ID NO:24);
- D-Phe-c(Cys-His-D-(Et)Tyr-hArg-Bip-β-Ala-D-Cys)-Thr-NH2 (SEQ ID NO:26);
- D-Phe-c(Cys-His-D-Phe-Arg-Bip-β-Ala-D-Cys)-Thr-NH2 (SEQ ID NO:25);
- D-Phe-c(Cys-His-D-Phe-hArg-Bip-β-Ala-D-Cys)-Thr-NH2 (SEQ ID NO:26);
- and
- Ac-hCha-c(Asp-His-D-Phe-Arg-Trp-Gaba-Lys)-NH2 (SEQ ID NO:11);
- or a pharmaceutically acceptable salt thereof.
8 more elements
Dependencies are inferred from the claim text.