Synthetic anti-inflammatory peptides and use thereof
AssigneeCarmel-Haifa University Economic Corp. Ltd.
InventorsAmiram Ariel, Aviv Lutaty
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Abstract
The present invention is directed to synthetic anti-inflammatory peptides and use thereof in the treatment and prevention of inflammatory and fibrotic conditions. Specifically, the invention relates in some embodiments to short isolated peptides having the amino acid sequence Phe-Lys-Glu (FKE), Tyr-Lys-Glu (YKE) or comprising a plurality of these sequences that may be flanked by Ala/Gly (A/G) linkers. The invention further relates in some embodiments to methods for inhibiting scar formation and for treating and alleviating IL-10 dependent conditions.
Claims12
A method of treating or inhibiting inflammation in a subject in need thereof identified as being afflicted with a disorder associated with an inappropriate or detrimental inflammatory response, comprising administering to the subject a pharmaceutical composition comprising a synthetic or recombinant peptide consisting of FKE (SEQ ID NO:
- 1), or 2-5 repeated FKE sequences,
- wherein said peptide may be chemically derivatized at the N- and/or C-terminus by non-peptide stabilizing chemical groups, and
- wherein said composition is used for inhibiting inflammation-induced fibrosis in said subject, or for inhibiting scar formation in said subject.
A method for inhibiting inflammation-induced fibrosis and scar formation in a subject in need thereof, comprising the step of administering to the subject a pharmaceutical composition comprising the peptide consisting of FKE (SEQ ID NO:
- 1), which may be chemically derivatized at the N- and/or C-terminus by non-peptide stabilizing chemical groups, thereby inhibiting inflammation-induced fibrosis and scar formation in said subject.
Dependencies are inferred from the claim text.