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US 9,850,273 B2Granted
Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective treatment of menopausal symptoms and for prevention of the occurrence of breast cancer
AssigneeEvestra, Inc.
InventorsKlaus Nickisch, Bindu Santhamma, Hareesh Nair, Walter Elger
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Abstract
Described herein are compositions and methods for hormone replacement therapy that address the shortcomings of the existing methods. Described herein are pharmaceutically effective partial agonistic antiprogestins. The combined application of estrogens (such as estradiol, estriol and conjugated estrogens) and the disclosed partial agonistic antiprogestins can be used in hormone replacement therapy.
Claims13
A pharmaceutical composition comprising an estrogen and a partial agonistic antiprogestin, wherein the partial agonistic antiprogestin has the formula (I):
- wherein at least one of X, Y, and Z is not a carbon atom.
Dependencies are inferred from the claim text.