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US 9,850,267 B2Granted
Crystalline fosaprepitant dicyclohexylamine salt and its preparation
AssigneeNavinta LLC
InventorsJigneshkumar Jasubhai Patel, Raja Jeyakumar John Muthiah
Life of this patent
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Abstract
The present invention provides dicyclohexylamine salt of fosaprepitant (fosaprepitant DCHA), a process for preparing fosaprepitant DCHA, and a use of fosaprepitant DCHA in the preparation of pharmaceutically acceptable fosaprepitant dimeglumine with high purity. Fosaprepitant dimeglumine is prepared by treating fosaprepitant DCHA with an acid to form fosaprepitant, followed by adding N-methyl-D-glucamine to fosaprepitant.
Claims3
A crystalline fosaprepitant di(dicyclohexylamine) salt of formula II:
- having an X-ray powder diffraction pattern with peaks at about 4.52, 8.29, 13.17, 17.23, 18.31, and 22.51±0.2° 2θ.
A crystalline fosaprepitant di(dicyclohexylamine) salt of of formula II:
- having Fourier transform IR spectra showing absorptions at about 1061, 1133, 1170, 1281, 1450, 1509, 1678, 2525, 2858, 2937, and 3395 cm−1.
Dependencies are inferred from the claim text.