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US 9,850,247 B2Granted
Pyrimidopyrimidinones useful as Wee-1 kinase inhibitors
AssigneeAlmac House
InventorsTimothy Harrison, Graham Trevitt, Peter Robin Hewitt, Colin Roderick O'Dowd, Frank Burkamp, Andrew John Wilkinson, Steven D. Shepherd, Hugues Miel
Life of this patent
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Abstract
The present invention relates to compounds that are useful as inhibitors of the activity of Wee-1 kinase. The present invention also relates to pharmaceutical compositions comprising these compounds and to methods of using these compounds in the treatment of cancer and methods of treating cancer.
Claims20
A compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is a phenyl ring substituted with alkyl and/or halogen;
- R2 and R3 are independently selected from the group consisting of a hydrogen atom, a deuterium atom, an optionally substituted alkyl group, an optionally substituted cycloalkyl group, an optionally substituted alkoxy group, an optionally substituted amino group, an optionally substituted aryl group and an optionally substituted heteroaryl group;
- or R2, R3 and the carbon atom to which they are both attached, as taken together, form an optionally substituted cycloalkyl group or an optionally substituted heterocyclyl group;
- R4 is a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted aryl group or an optionally substituted heteroaryl group;
- or R4 and R2 or R3 and the ring atoms to which they are attached, as taken together, form an optionally substituted heterocyclyl group;
- and
- R5 is an optionally substituted phenyl ring or a heterocyclic bicyclic ring, wherein the heterocyclic bicyclic ring comprises a phenyl ring that is bound to the amino group.
5 more elements
Dependencies are inferred from the claim text.