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US 9,850,246 B2Granted
Process for making CGRP receptor antagonists
AssigneeMerck Sharp & Dohme Corp.
InventorsFrank Chen, Carmela Molinaro, W. Peter Wuelfing, Nobuyoshi Yasuda, Jianguo Yin, Yong-Li Zhong, Joseph Lynch, Teresa Andreani
Life of this patent
Estimating the term…
Abstract
The invention encompasses a novel process for making piperidinone carboxamide indane and azainane derivatives, which are CGRP receptor antagonists useful for the treatment of migraine.
Claims3
Crystalline (S)-N-((3S,5S,6R)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl)-2′-oxo-1′,2′,5,7-tetrahydrospiro[cyclopenta[b]pyridine-6,3′-pyrrolo[2,3 -b]pyridine]-3 -carboxamide monohydrate.
Dependencies are inferred from the claim text.