Triazolopyridine derivatives as modulators of TNF activity

A compound as represented by formula (IIB) or an N-oxide thereof, or a pharmaceutically acceptable salt or solvate thereof,

• wherein
• V represents C—R22 or N;
• R21 represents hydroxy(C1-6)alkyl;
• or R21 represents (C3-7)cycloalkyl or (C3-7)heterocycloalkyl, either of which groups is optionally substituted by one, two, or three substituents independently selected from halogen, halo(C1-6)alkyl, cyano, cyano-(C1-6)alkyl, nitro, nitro(C1-6)alkyl, C1-6 alkyl, trifluoro-methyl, trifluoroethyl, C2-6 alkenyl, hydroxy, hydroxy-(C1-6)alkyl, C1-6 alkoxy, difluoromethoxy, trifluoro-methoxy, trifluoroethoxy, C1-6 alkylthio, C1-6 alkylsulphinyl, C1-6 alkylsulphonyl, C1-6 alkylsulphonyl, (C1-6)alkylsulphonyl(C1-6)alkyl, oxo, amino, C1-6 alkyl-amino, di(C1-6)alkylamino, C2-6 alkylcarbonylamino, (C2-6)alkylcarbonylamino(C1-6)alkyl, C2-6 alkoxycarbonyl-amino, C1-6 alkylsulphonylamino, (C1-6)alkylsulphonyl-amino(C1-6)alkyl, formyl, C2-6 alkylcarbonyl, carboxy, carboxy(C1-6)alkyl, C2-6 alkoxycarbonyl, morpholinyl-(C1-6)alkoxycarbonyl, C2-6 alkoxycarbonyl(C1-6)alkyl, C2-6 alkoxycarbonylmethylidenyl, tetrazolyl(C1-6)alkyl, amino-carbonyl, C1-6 alkylaminocarbonyl, di(C1-6)alkylamino-carbonyl, aminosulphonyl, C1-6 alkylaminosulphonyl, di(C1-6)alkylaminosulphonyl, (C1-6)alkylsulphoximinyl, [(C1-6)alkyl][N—(C1-6)alkyl]sulphoximinyl, (C1-6)alkylsulphonylaminocarbonyl, (C2-6)alkylcarbonylamino-sulphonyl, (C1-6)alkoxyaminocarbonyl, tetrazolyl and hydroxyoxadiazolyl;
• R22 represents hydrogen, halogen or C1-6 alkyl;
• R23 represents hydrogen, C1-6 alkyl, trifluoromethyl or C1-6 alkoxy;
• E represents —CH2;
• R12 represents hydrogen or halogen;
• R15 represents hydrogen, halogen, C1-6 alkyl, trifluoromethyl, C1-6 alkoxy, difluoromethoxy, or trifluoromethoxy;
• and
• R16 represents hydrogen, halogen, cyano, C1-6 alkyl, trifluoromethyl, difluoromethoxy, or amino.