Pyridine derivatives as soft rock inhibitors
AssigneeRedx Pharma PLC
InventorsSandro Boland, Arnaud Bourin, Olivier Defert, Dirk Leysen
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Abstract
The present invention relates to new kinase inhibitors, more specifically ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In particular, the present invention relates to new ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease. In addition, the invention relates to methods of treatment and use of said compounds in the manufacture of a medicament for the application to a number of therapeutic indications including Respiratory and Gastro-Intestinal diseases.
Claims7
A method of treatment of fibrosis, wherein the method comprises administering to a patient in need thereof, a therapeutically effective amount of a compound of Formula I or a stereoisomer, tautomer, racemic, salt, hydrate, or solvate thereof,
- Wherein
- R1 is selected from hydrogen and C1-20alkyl;
- X1 is hydrogen or halo;
- X2 is —C(═O)—NH— or —NH—C(═O)—;
- Cy is an optionally substituted group selected from aryl and heteroaryl;
- X3 is selected from the group consisting of —S—, —O—, and —NR2—;
- R2 is hydrogen or C1-6alkyl;
- Het1 is 2-oxotetrahydrofuranyl optionally substituted with one or more C1-6alkyl-;
- and
- A1 and A2 are each independently a direct bond or an optionally substituted C1-6alkylene.
Dependencies are inferred from the claim text.