US 9,850,225 B2Granted

Compounds useful as immunomodulators

AssigneeBristol-Myers Squibb Company

InventorsLouis S. Chupak, Min Ding, Scott W. Martin, Xiaofan Zheng, Piyasena Hewawasam, Timothy P. Connolly, Ningning Xu, Kap-Sun Yeung, Juliang Zhu, David R. Langley, Paul Michael Scola

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Abstract

The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Claims15

Dependent claims

A compound of formula (I):

or a pharmaceutically acceptable salt thereof, wherein:
m is 0, 1, or 2;
R1 is selected from hydrogen, —(CH2)nX and —(CH2)nAr;
wherein
n is 1, 2, 3, or 4;
X is selected from —CH3, —CF3, CN, —CO2R4, —C(O)NH2, OR4, and pyrrolidonyl;
R4 is H or C1-C3alkyl;
Ar is selected from benzodioxanyl, indazolyl, isoquinolinyl, isoxazolyl, naphthyl, oxadiazolyl, phenyl, pyridinyl, pyrimidinyl, and quinolinyl;
wherein each ring is optionally substituted with 1, 2, 3, or 4 substituents independently selected from C1-C4alkoxy, C1-C4alkoxycarbonyl, C1-C4alkoxycarbonylamino, C1-C4alkyl, (C1-C4alkyl)carbonyl, (C1-C4alkyl)sulfonyl, amido, aminocarbonyl, aminocarbonyl(C1-C3alkyl), —(CH2)qCO2C1-C4alkyl, —(CH2)qOH, carboxy, cyano, formyl, halo, haloC1-C4alkyl, haloC1-C4alkoxy, nitro, phenyl optionally substituted with one cyano group, phenyloxy optionally substituted with one halo group, phenylcarbonyl, pyrrole, and tetrahydropyran;
and wherein q is 0, 1, 2, 3, or 4;
R2 is selected from
wherein Y is selected from cyano, chloro, and methyl;
Rq is selected from hydrogen, C1-C3alkyl, and benzyl;
R3 is selected from
wherein Rz is selected from C1-C3alkyl, C1-C3alkylsulfonylC1-C3alkyl, C1-C3alkylsulfoxylC1-C3alkyl, amidoC1-C3alkyl, aminoC1-C4alkyl, carboxyC1-C3alkyl, cyanoC1-C3alkyl, dimethylamidoC1-C3alkyl, dimethylaminoC1-C4alkyl, haloC1-C3alkyl, hydroxyC1-C3alkyl, C1-C3alkylsulfanylC1-C3alkyl, pyridinylC1-C3alkyl, tetrazolylC1-C3alkyl, imidazolylC1-C3alkyl wherein the imidazole is optionally substituted with methyl or a benzyl group, phenylC1-C3alkyl wherein the phenyl is optionally substituted with cyano, methyl, or hydroxy, thiazolylC1-C3alkyl;
R6 is selected from hydrogen, benzyl, and methyl;
each R6′ is independently selected from hydrogen and methyl;
R7 is selected from hydrogen, C1-C3alkyl, and benzyl;
o is 1 or 2;
X is CH or N;
p is 0 or 1;
Ra is hydroxy;
and
Rb is selected from hydrogen, benzyl, and methyl;
or
R3 and Rq, together with the nitrogen atom to which they are attached, form a ring selected from
s is 0 or 1;
z is 1, 2, or 3;
and
R8 is selected from hydroxy and —NHSO2R11;
R9 is selected from hydrogen and —CO2H;
R10 is selected from halo and hydroxy;
R11 is selected from trifluoromethyl, cyclopropyl, C1-C3alkyl, dimethylamino, and imidazolyl substituted with a methyl group;
Q is selected from CH2, S, O, and NCH3;
and
R5 is selected from C2-C4alkenyl, C1-C4alkyl, cyano, methoxy, halo, and trifluoromethyl.

33 more elements

A compound selected from

N-(2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)ethyl)acetamide;
(R)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxypropanoic acid;
(S)-4-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxybutanoic acid;
(S)-1-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzyl)piperidine-2-carboxylic acid;
N-(2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)ethyl)acetamide;
(S)-4-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxybutanoic acid;
(R)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxypropanoic acid;
(R)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzyl)piperidine-2-carboxylic acid;
(S)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-6-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-4-(2-(3-cyanobenzyloxy)-4-((2-methylbiphenyl-3-yl)methoxy)benzylamino)-3-hydroxybutanoic acid;
(2S,3S)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(2R,3R)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(2R,3S)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(R)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-2-(hydroxymethyl)-3-methylbutanoic acid;
(S)-3-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-4-hydroxybutanoic acid;
(R)-3-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-4-hydroxybutanoic acid;
(R)-2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
N-(2-((2-(benzyloxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((3-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(2,2,2-trifluoroethoxyl)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-propoxybenzyl)amino)ethyl)acetamide;
N-(2-((2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-(2-hydroxyethoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
2-(2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)acetamide;
methyl 5-(2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)pentanoate;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-phenethoxybenzyl)amino)ethyl)acetamide;
methyl 3-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)benzoate;
N-(2-((2-(3-hydroxypropoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
methyl 4-(2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)butanoate;
N-(2-((2-((3-(hydroxymethyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-(hydroxymethyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
4-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)benzamide;
N-(2-((2-((4-acetylbenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((2-(methylsulfonyl)benzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-(3-methoxypropoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
4-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)benzoic acid;
N-(2-((2-ethoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((2-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-(tert-butyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((4-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2,6-difluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((3-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((4-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-chlorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-chlorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(naphthalen-2-ylmethoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((2-nitrobenzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((4-nitrobenzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3,4-difluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2,5-difluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3,5-bis(trifluoromethyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3,5-difluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(naphthalen-1-ylmethoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2,4-difluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3,5-dimethylbenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((2-(trifluoromethyl)benzyl)oxy)benzyl)amino)ethyl)acetamide;
methyl 4-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)benzoate;
N-(2-((2-((4-chlorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3,4-dichlorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-fluoro-3-methylbenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2,3-difluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-chloro-2-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-benzoylbenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(quinolin-8-ylmethoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((3-nitrobenzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-(2-fluorophenoxyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-(4-fluorophenoxyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-fluoro-3-(trifluoromethyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-fluoro-5-(trifluoromethyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-fluoro-5-(trifluoromethyl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((3-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-chloro-2-(trifluoromethyl)quinolin-6-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((4-(methylsulfonyl)benzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-(difluoromethoxy)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-methoxybenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((2-(trifluoromethoxy)benzyl)oxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-(difluoromethoxy)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2′-cyano-[1,1′-biphenyl]-4-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-methoxybenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-chloro-5-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2,6-difluoro-3-methoxybenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-fluoro-3-methoxybenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((2-fluoro-5-methylbenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((5-cyano-2-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-fluoro-5-methoxybenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-bromo-2-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((1H-indazol-5-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((1-(tetrahydro-2H-pyran-2-yl)-1H -indazol-5-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(pyrimidin-4-ylmethoxy)benzyl)amino)ethyl)acetamide;
methyl 2-(3-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)phenyl)acetate;
N-(2-((2-((1H-indazol-6-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
methyl 3-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)-4-fluorobenzoate;
N-(2-((2-((5-methyl-1,2,4-oxadiazol-3-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
tert-butyl 3-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)benzoate;
N-(2-((2-((3-fluoro-5-(trifluoromethoxy)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3,5-dimethoxybenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((4-fluoro-3-methylbenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((5-chloro-2-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-chloro-4-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(pyridin-4-ylmethoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-(1H-pyrrol-1-yl)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-fluoro-5-methylbenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(5-methylisoxazol-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-((3-(difluoromethoxy)benzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-(pyridin-3-ylmethoxy)benzyl)amino)ethyl)acetamide;
N-(2-((2-(isoquinolin-1-ylmethoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
tert-butyl (3-((2-(((2-acetamidoethyl)amino)methyl)-5-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)phenoxy)methyl)phenyl)carbamate;
(S)—N-(2-((4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)-2-((5-oxopyrrolidin-2-yl)methoxy)benzyl)amino)ethyl)acetamide;
(S)-4-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxybutanoic acid;
2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(2R,3S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(2R,3R)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-3-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-hydroxybutanoic acid;
(R)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-3-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-hydroxybutanoic acid;
N-(2-(2-((4-cyanopyridin-2-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)ethyl)acetamide;
(R)-2-(2-((4-cyanopyridin-2-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(2-((4-cyanopyridin-2-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)piperidine-2-carboxylic acid;
(S)-4-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(R)-2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(2R,3S)-2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(2S,3S)-2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(2R,3R)-2-((2-((3-cyanobenzyl)oxy)-6-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(R)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-6-methoxybenzyl)amino)-3-hydroxypropanoic acid;
(S)-4-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-6-methoxybenzyl)amino)-3-hydroxybutanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-6-methoxybenzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-6-methoxybenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((2-(4-cyanobutoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-4-((2-(4-cyanobutoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-1-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-(3-cyanobenzyloxyl)benzyl)piperidine-2-carboxylic acid;
(R)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-(3-cyanobenzyloxyl)benzylamino)-3-hydroxypropanoic acid;
(S)-4-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-(3-cyanobenzyloxyl)benzylamino)-3-hydroxybutanoic acid;
(R)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-(3-cyanobenzyloxyl)benzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-(3-cyanobenzyloxyl)benzylamino)-3-hydroxy-2-methylpropanoic acid;
N-(2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-(3-cyanobenzyloxyl)benzylamino)ethyl)acetamide;
5-((5-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((2-hydroxyethylamino)methyl)-4-methylphenoxy)methyl)nicotinonitrile;
(S)-1-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(R)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)-3-hydroxypropanoic acid;
(S)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-1-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(R)-2-(4-(2-chloro-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)succinic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(3-hydroxyphenyl)propanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(methylthio)propanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-2-(4-hydroxyphenyl)acetic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3,3,3-trifluoropropanoic acid;
(2R,3R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1H-imidazol-4-yl)propanoic acid;
1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)pyrrolidine-2-carboxylic acid;
(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(5-hydroxy-1H-indol-3-yl)propanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1-methyl-1H-indol-3-yl)propanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)propanoic acid;
3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-(((2-hydroxyethyl)amino)methyl)phenoxy)methyl)benzonitrile;
(S)-2-(benzyl(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(dimethylamino)propanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-6-(dimethylamino)hexanoic acid;
(2S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-(methylsulfinyl)butanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)succinic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1-methyl-1H-imidazol-4-yl)propanoic acid;
1-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)cyclopropanecarboxylic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(thiazol-2-yl)propanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-methoxy-3-methylbutanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-cyanopropanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(2-hydroxyphenyl)propanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-(methylsulfonyl)butanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)(methyl)amino)-3-hydroxypropanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-methoxypropanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1H-pyrrolo[2,3-b]pyridin-3-yl)propanoic acid;
(S)-3-(1-benzyl-1H-imidazol-4-yl)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)propanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(4-hydroxyphenyl)propanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)(methyl)amino)propanoic acid;
(2S,3S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(2S,3R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2,3-dicarboxylic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1H-imidazol-4-yl)-2-methylpropanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1H-indol-3-yl)propanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)butanoic acid;
(R)-3-(benzyloxy)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)propanoic acid;
(2R,3S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(2S,4S)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid;
(2S,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid;
(R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(2R,4S)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-(methylsulfonyl)butanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)butanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-(methylthio)butanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)(methyl)amino)succinic acid;
(2S,3R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-3-hydroxypyrrolidine-2-carboxylic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-hydroxybutanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(thiazol-4-yl)propanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1-methyl-1H-imidazol-5-yl)propanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(thiazol-4-yl)propanoic acid;
1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)azetidine-2-carboxylic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-3-methylbutanoic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-2-(1H-indol-3-yl)acetic acid;
3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-(((2-hydroxy-3-morpholinopropyl)amino)methyl)phenoxy)methyl)benzonitrile;
4-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)morpholine-3-carboxylic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-2-(hydroxymethyl)-3-methylbutanoic acid;
(2S,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-fluoropyrrolidine-2-carboxylic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4,4,4-trifluorobutanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(3-cyanophenyl)propanoic acid;
2-benzyl-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(2S,3S)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-3-hydroxypyrrolidine-2-carboxylic acid;
4-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-1-methylpiperidine-4-carboxylic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(pyridin-2-yl)propanoic acid;
(S)-4-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)thiomorpholine-3-carboxylic acid;
3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-(((2-methyl-1-(4-methylpiperazin-1-yl)propan-2yl)amino)methyl)phenoxy)methyl)benzonitrile;
1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-methylpiperazine-2-carboxylic acid;
3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-(((2-hydroxy-3-(2-oxopyrrolidin-1-yl)propyl)amino)methyl)phenoxy)methyl)benzonitrile;
5-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine-4-carboxylic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(2H-tetrazol-2-yl)propanoic acid;
(R)-3-(1-benzyl-1H-imidazol-4-yl)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)propanoic acid;
3-((2-((((1H-tetrazol-5-yl)methyl)amino)methyl)-4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)phenoxy)methyl)benzonitrile;
(S)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(R)-2-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-4-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-1-(3-chloro-2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;
N-(2-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
(R)-2-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-1-(3-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
N-(2-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
(S)-2-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-4-((3-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(R)-2-((5-chloro-4-((2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-2-((3-cyanobenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((5-chloro-4-((2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-2-((3-cyanobenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
3-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)oxetane-3-carboxylic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-4-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
N-(2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
(R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-4-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
N-(2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
(S)-2-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(R)-2-(2-((5-bromopyridin-3-yl)methoxy)-5-chloro-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
N-(2-(2-((5-bromopyridin-3-yl)methoxy)-5-chloro-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)ethyl)acetamide;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)-N-(methylsulfonyl)piperidine-2-carboxamide;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)-N-(N,N-dimethylsulfamoyl)piperidine-2-carboxamide;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)-N-(trifluoromethylsulfonyl)piperidine-2-carboxamide;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)-N-(cyclopropylsulfonyl)piperidine-2-carboxamide;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)-N-(isopropylsulfonyl)piperidine-2-carboxamide;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)-N-(1-methyl-1H-imidazol-4-ylsulfonyl)piperidine-2-carboxamide;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-N-((4-methylpiperazin-1-yl)sulfonyl)piperidine-2-carboxamide;
(R)-2-(5-chloro-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-2-hydroxybenzylamino)-3-hydroxy-2-methylpropanoic acid;
N-(2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)ethyl)acetamide;
(S)-4-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxybutanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(R)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-4-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxybutanoic acid;
N-(2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)ethyl)acetamide;
(S)-1-(2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(R)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
N-(2-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)ethyl)acetamide;
(S)-2-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-4-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-1-(4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)piperidine-2-carboxylic acid;
(S)-2-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
N-(2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)ethyl)acetamide;
(S)-4-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxybutanoic acid;
(S)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxypropanoic acid;
(S)-1-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(S)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-1-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
N-(2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-ethylbenzylamino)ethyl)acetamide;
(S)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-ethylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-ethylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
N-(2-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-vinylbenzylamino)ethyl)acetamide;
(S)-1-(2-(3-cyanobenzyloxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-vinylbenzyl)piperidine-2-carboxylic acid;
N-(2-(2-(4-cyanobutoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)ethyl)acetamide;
(S)-4-(2-(4-cyanobutoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxybutanoic acid;
(S)-1-(2-(4-cyanobutoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(S)-2-(2-(4-cyanobutoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(2-methylbiphenyl-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;
N-(2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
(S)-4-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-1-(5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(R)-2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
N-(2-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)ethyl)acetamide;
5-((5-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((2-hydroxyethylamino)methyl)-4-methylphenoxy)methyl)nicotinonitrile;
(S)-4-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)-3-hydroxybutanoic acid;
(S)-2-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(R)-2-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)-3-hydroxypropanoic acid;
(R)-2-(4-(2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyloxy)-2-((5-cyanopyridin-3-yl)methoxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-((5-bromo-4-((2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-2-((3-cyanobenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-1-(5-bromo-4-((2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-2-((3-cyanobenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(S)-4-((5-bromo-4-((2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-2-((3-cyanobenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
N-(2-((5-bromo-4-((2-cyano-3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)benzyl)oxy)-2-((3-cyanobenzyl)oxy)benzyl)amino)ethyl)acetamide;
(S)-4-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxybutanoic acid;
N-(2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)ethyl)acetamide;
(S)-2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxypropanoic acid;
(S)-1-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)piperidine-2-carboxylic acid;
(R)-2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
5-((4-bromo-5-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-2-((2-hydroxyethylamino)methyl)phenoxy)methyl)nicotinonitrile;
(R)-1-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)piperidine-2-carboxylic acid;
(R)-2-((2-((5-cyano-4-methylpyridin-3-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(R)-2-((2-((3-carbamoylbenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(R)-2-((2-((3-carbamoylbenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-4-((2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-1-(2-((5-cyanopyridin-3-yl)methoxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;
(S)-4-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-4-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxybutanoic acid;
(R)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxypropanoic acid;
(R)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(2-((3-cyano-4-fluorobenzyl)oxy)-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;
and
N-(2-((2-methoxy-4-((2-methyl-[1,1′-biphenyl]-3-yl)methoxy)benzyl)amino)ethyl)acetamide;
or a pharmaceutically acceptable salt thereof.

335 more elements

A compound selected from

N-(2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)ethyl)acetamide;
(S)-4-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxybutanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(R)-2-((2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
N-(2-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)ethyl)acetamide;
(S)-4-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxybutanoic acid;
N-(2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)ethyl)acetamide;
(S)-1-(2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(S)-2-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)-3-hydroxypropanoic acid;
(R)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-4-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxypropanoic acid;
(S)-2-((2-((3-cyano-4-fluorobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methylbenzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)piperidine-2-carboxylic acid;
(S)-2-((4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-5-methyl-2-(pyridin-3-ylmethoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
N-(2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)ethyl)acetamide;
(S)-4-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxybutanoic acid;
(S)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxypropanoic acid;
(S)-1-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
(S)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-1-(2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
N-(2-(2-(4-cyanobutoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)ethyl)acetamide;
(S)-1-(2-(4-cyanobutoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzyl)piperidine-2-carboxylic acid;
and
(S)-2-(2-(4-cyanobutoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-5-methylbenzylamino)-3-hydroxy-2-methylpropanoic acid;
or a pharmaceutically acceptable salt thereof.

26 more elements

A compound selected from

(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(R)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(S)-4-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(S)-2-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-(2-((5-bromopyridin-3-yl)methoxy)-5-chloro-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
(2R,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid;
2-((5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(1H-imidazol-4-yl)-2-methylpropanoic acid;
(2S,4S)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid;
(2S,4R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypyrrolidine-2-carboxylic acid;
(2S,3R)-1-(5-chloro-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-3-hydroxypyrrolidine-2-carboxylic acid;
and
3-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-(((2-methyl-1-(4-methylpiperazin-1-yl)propan-2-yl)amino)methyl)phenoxy)methyl)benzonitrile;
or a pharmaceutically acceptable salt thereof.

15 more elements

A compound selected from

N-(2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)ethyl)acetamide;
(S)-4-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxybutanoic acid;
(S)-2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
(S)-1-(5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(S)-2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(R)-2-((5-bromo-2-((3-cyanobenzyl)oxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-4-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxybutanoic acid;
N-(2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)ethyl)acetamide;
(S)-2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxypropanoic acid;
(S)-1-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)piperidine-2-carboxylic acid;
(R)-2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzylamino)-3-hydroxy-2-methylpropanoic acid;
5-((4-bromo-5-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)-2-((2-hydroxyethylamino)methyl)phenoxy)methyl)nicotinonitrile;
and
(R)-1-(5-bromo-2-((5-cyanopyridin-3-yl)methoxy)-4-(3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyloxy)benzyl)piperidine-2-carboxylic acid;
or a pharmaceutically acceptable salt thereof.

13 more elements

A compound selected from

(S)-2-((5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((5-(ethoxycarbonyl)pyridin-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-5-((2-(((2-carboxy-1-hydroxypropan-2-yl)amino)methyl)-4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)phenoxy)methyl)nicotinic acid;
(S)-5-((2-(((4-amino-1-carboxybutyl)amino)methyl)-4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)phenoxy)methyl)nicotinic acid;
(S)-5-amino-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)pentanoic acid;
(S)-6-amino-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)hexanoic acid;
(S)-4-amino-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)butanoic acid;
(2S,5S)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-5-hydroxypiperidine-2-carboxylic acid;
(2S,4R)-1-(5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)-4-hydroxypiperidine-2-carboxylic acid;
(S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(pyridin-2-yl)propanoic acid;
(S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(pyridin-3-yl)propanoic acid;
(S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-(pyridin-4-yl)propanoic acid;
(S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)pentanedioic acid;
2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)acetic acid;
ethyl (5-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-formylphenoxy)methyl)pyridin-3-yl)carbamate;
(S)-2-((5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((5-((ethoxycarbonyl)amino)pyridin-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
N-(4-((4-chloro-5-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-formylphenoxy)methyl)pyridin-2-yl)acetamide;
(S)-2-((2-((2-acetamidopyridin-4-yl)methoxy)-5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-2-((5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((5-(methylsulfonyl)pyridin-3-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(5-chloro-4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2-[(5-methanesulfonylpyridin-3-yl)methoxy]phenyl)methanol;
(S)-2-((5-chloro-2-((2-chloro-6-methoxypyridin-4-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(2S)-2-{[(5-chloro-4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2-[(2-methoxypyridin-4-yl)methoxy]phenyl)methyl]amino}-3-hydroxy-2-methylpropanoic acid;
(5-chloro-4-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2-[(2-methoxypyridin-4-yl)methoxy]phenyl)methanol;
(S)-1-(5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((2-methoxypyridin-4-yl)methoxy)benzyl)piperidine-2-carboxylic acid;
(S)-2-((5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((2-(dimethylcarbamoyl)pyridin-4-yl)methoxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
4-(4-chloro-5-{[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-methylphenyl]methoxy}-2-(hydroxymethyl)phenoxymethyl)-N,N-dimethylpyridine-2-carboxamide;
5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((3-(methylsulfonyl)benzyl)oxy)benzaldehyde;
(S)-2-((5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((3-(methylsulfonyl)benzyl)oxy)benzyl)amino)-3-hydroxy-2-methylpropanoic acid;
(S)-4-amino-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-oxobutanoic acid;
(S)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)succinic acid;
(R)-4-amino-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-4-oxobutanoic acid;
(R)-2-((5-chloro-2-((5-cyanopyridin-3-yl)methoxy)-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)succinic acid;
(S)-1-(5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((2-methoxy-5-(methoxycarbonyl)benzyl)oxy)benzyl)piperidine-2-carboxylic acid;
S)-1-(2-((5-carboxy-2-methoxybenzyl)oxy)-5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(S)-1-(2-(benzyloxy)-5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
(S)-1-(5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)-2-((2-methoxybenzyl)oxy)benzyl)piperidine-2-carboxylic acid;
and
(S)-2-((2-(2-amino-2-oxoethoxy)-5-chloro-4-((3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-2-methylbenzyl)oxy)benzyl)amino)-3-hydroxypropanoic acid;
or a pharmaceutically acceptable salt thereof.

35 more elements

Dependencies are inferred from the claim text.

Facts

Application: 14/681,772Filed 8 Apr 2015 · us provisional application
Priority: 14 Apr 2014
Published: US 2015/0291549 A115 Oct 2015
Granted: 26 Dec 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification61 codes

C07D 319/18
Condensed with one six-membered ring: ethylenedioxybenzenes, not substituted on the hetero ring
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/277
Nitriles; Isonitriles: having a ring, e.g. verapamil
A61K 31/357
Having oxygen as the only ring hetero atom, e.g. fungichromin: having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel