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US 9,850,219 B1Granted
Phenothiazine derivatives and methods of use thereof
AssigneeAcenda Pharma, Inc.
InventorsHaiyung Cheng, Chi-Feng Lin, Jhen-Hua Shih, Alexander C. H. Wu
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Abstract
The present disclosure relates to phenothiazine derivatives such as conjugates of phenothiazine compounds, as well as pharmaceutical compositions thereof. The present disclosure also relates to a method of making and the use of such compounds for treating cancer, e.g., a lung cancer, a colon cancer, breast cancer or pancreatic cancer.
Claims20
A method of treating non-small cell lung cancer (NSCLC), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- Oligo is an oligomer or a co-oligomer selected from the group consisting of —[CH2CH(OR1)CH2O]m—R2, —[CH2CH2O]n—R3, —[CH2CH(OR1)CH2O]m—[CH2CH2O]n—R2, and —[CH2CH2O]n—[CH2CH(OR1)CH2O]m—R2;
- R is H, halo, C1-C4 alkyl substituted with one or more halo, or —S—C1-C4 alkyl;
- each of R1, R2 and R3 independently is H or C1-C4 alkyl;
- X is a bond, C(O), C(O)O, or C(O)CH2O;
- m is an integer ranging from 2 to 16, and
- n is an integer ranging from 3 to 16.
4 more elements
Dependencies are inferred from the claim text.