Inhibitors of NEDD8-activating enzyme
AssigneeMillennium Pharmaceuticals, Inc.
InventorsAshley Sue McCarron, Todd B. Sells, Matthew Stirling, Stephen G. Stroud
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Abstract
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
Claims15
A chemical entity comprising a hydrochloride salt of the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate or a pharmaceutically acceptable solvate thereof, wherein said chemical entity is substantially crystalline Form II.
A prodrug of a chemical entity, wherein:
- the chemical entity is the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate or a pharmaceutically acceptable salt thereof;
- and
- the prodrug is a carbamate or amide of an NH group of the chemical entity, or an ether or ester of an OH group of the chemical entity.
Dependencies are inferred from the claim text.