Method for preparing rosuvastatin sodium

A method for preparing rosuvastatin sodium, comprising the steps of:

• (1) reducing a compound of 4-p-fluorophenyl-6-isopropyl-2-(N-methyl-methylsulfonylamino)pyrimidine-5-carboxylic acid (VII) in an organic solvent by a borohydride in the presence of an alkyl-substituted chlorosilane and an assistant at a reaction temperature of 0-100° C. for a reaction time of 6-72 h to prepare a compound of 4-p-fluorophenyl-5-hydroxymethyl-6-isopropyl-2-(N-methyl-methylsulfonylamino) pyrimidine (VIII);
• (2) performing salt formation by a phosphorus substitution reaction of compound VIII with a triphenyl phosphonium salt in an organic solvent at a reaction temperature of 0-150° C. for a reaction time of 1-24 h to obtain a ((4-p-fluorophenyl-6-isopropyl-2-(N-methyl-methylsulfonylamino)-5-pyridyl)-methyl)triphenyl phosphonium salt (IX);
• (3) performing a stereoselective Michael addition reaction of (S)-trans-4,5-dihydroxy-pent-2-enoate (II) with furfural (III) in the presence of a base to prepare 2-((4R,6S)-2-(furan-2-yl)-6-hydroxymethyl-1,3-dioxane-4-yl)acetate (IV);
• (4) performing a sodium hypochlorite oxidization of the compound IV in an organic solvent in the presence of sodium bicarbonate and potassium/sodium bromide under the catalysis of a 2,2,6,6-tetramethylpiperidine oxynitride to prepare a compound of 2-((4R,6S)-2-(furan-2-yl)-6-formacyl-1,3-dioxane-4-yl)acetate (V);
• (5) performing an olefination reaction of the compound V with a (4-p-fluorophenyl-6-isopropyl-2-(N-methyl-methylsulfonylamino)pyrimid-5-yl)-methyl substituted phosphonium salt (IX) or phosphate in the presence of a base to prepare 2-((4R,6S)-6-(trans-2-(4-p-fluorophenyl-6-isopropyl-2-(N-methyl-methylsulfonylamino)pyrimid-5-yl)vinyl)-2-(furan-2-yl)-1,3-dioxane-4-yl)acetate (VI);
• (6) performing acid hydrolysis deprotection of the compound (VI) and then sodium salt formation with a base to prepare rosuvastatin sodium (I);
• the synthetic route of the rosuvastatin sodium being:
• wherein Y is PPh3X or —PO(OR′)2;
• X is bromine or boron tetrafluoride;
• R′ is ethyl or isopropyl;
• and R is a C1-C4 linear or branched alkyl group.