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US 9,850,204 B2Granted
Triple reuptake inhibitors and methods of their use
AssigneeSunovion Pharmaceuticals Inc.
InventorsLiming Shao, Fengjiang Wang, Scott C. Malcolm, Michael C. Hewitt
Life of this patent
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Abstract
Provided herein are bicyclic compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders. Compounds provided herein inhibit reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine (e.g., from the synaptic cleft) and modulate one or more monoamine transporter. Pharmaceutical formulations containing the compounds are also provided.
Claims23
A compound of formula (I)
- or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof;
- wherein:
- m is 0;
- n is 0, 1, or 2;
- X is hydrogen, (C3-C10)cycloalkyl, (C3-C10)cycloalkyl-(C1-C10)alkyl, (C1-C10)alkenyl, (C1-C10)alkynyl, (C1-C10)alkoxy, 6 to 10 membered aryl, (6 to 10 membered aryl)-(C1-C10)alkyl, —OR1, heteroalkyl, heteroalkenyl, or heteroalkynyl,
- Y and Z are each independently halogen, —CF3, —CN, —NH2, —NO2, dioxolano, (C1-C10)alkyl, (C3-C10)cycloalkyl, (C1-C10)alkenyl, (C1-C10)alkynyl, (C1-C10)alkoxy, (C3-C10)cycloalkoxy, or —OR2;
- or
- Y and Z, taken together, may form 5, 6 or 7 membered cycloalkyl;
- and
- R1 and R2 are each independently hydrogen, (C1-C10)alkyl, (C1-C10)alkenyl, (C1-C10)alkynyl, (C3-C10)cycloalkyl, (C3-C10)cycloalkyl-(C1-C10)alkyl, (C1-C10)alkoxy, 6 to 10 membered aryl, 6 to 10 membered heteroaryl, (6 to 10 membered aryl)-(C1-C10)alkyl, —SO2(C1-C10)alkyl, or —SO2-(6 to 10 membered aryl).
7 more elements
Dependencies are inferred from the claim text.