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US 9,850,202 B2Granted
Ionizable cationic lipid for RNA delivery
AssigneeArcturus Therapeutics, Inc.
InventorsJoseph E. Payne, Padmanabh Chivukula
Life of this patent
Estimating the term…
Abstract
What is described is a compound wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbons; L1 and L2 are the same or different, each a linear alkyl having 3 to 18 carbons; X1 and X3 are —CO—O—; X3 is S or O; L3 is a lower alkyl; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.
Claims20
A compound of formula I
- wherein
- R1 is a branched alkyl of 3, 4, 5, 6, 7, 8, or 9 carbons,
- R2 is a linear or branched alkyl of 1, 2, 3, 4, 5, 6, 7, 8, or 9 carbons, an alkenyl or alkynyl of 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbons, or cholesteryl,
- L1 and L2 are the same or different, each a linear alkylene or alkenylene of 3 or 4 carbons,
- X1 is —CO—O— whereby -L2-CO—O—R2 is formed,
- X2 is S or O,
- X3 is —CO—O— whereby -L1-CO—O—R1 is formed,
- L3 is a bond, or a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons,
- R3 is a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons, and
- R4 and R5 are the same or different, each hydrogen or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons;
- or a pharmaceutically acceptable salt thereof.
8 more elements
A compound of formula 2
- wherein
- R1 is branched alkyl of 3, 4, 5, 6, 7, 8, or 9 carbons,
- R2 is a linear or branched alkyl of 1, 2, 3, 4, 5, 6, 7, 8, or 9 carbons, an alkenyl or alkynyl of 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbons, or cholesteryl,
- L1 and L2 are the same or different, each a linear alkylene or alkenylene of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18 carbons,
- X1 is —CO—O— whereby -L2-CO—O—R2 is formed,
- X2 is S or O,
- X3 is-CO—O— whereby -L1-CO—O—R1 is formed,
- L3 is a bond, or a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons,
- R3 is a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons, and
- R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons;
- or a pharmaceutically acceptable salt thereof.
8 more elements
A compound of formula I
- wherein
- R1 and R2 are the same or different, each a linear or branched alkyl of 1, 2, 3, 4, 5, 6, 7, 8, or 9 carbons, an alkenyl or alkynyl of 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbons, or cholesteryl,
- L1 and L2 are propylene,
- X1 is —CO—O— whereby -L2-CO—O—R2 is formed,
- X2 is S or O,
- X3 is −CO—O— whereby -L1-CO—O—R1 is formed,
- L3 is a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons,
- R3 is a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons, and
- R4 and R5 are the same or different, each hydrogen or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons;
- or a pharmaceutically acceptable salt thereof.
7 more elements
A compound of formula 2
- wherein
- R1 and R2 are the same, each an alkyl of 1, 2, or 3 carbons,
- L1 and L2 are the same or different, each a linear alkylene or alkenylene of 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18 carbons,
- X1 is —CO—O— whereby -L2-CO—O—R2 is formed,
- X2 is S or O,
- X3 is —CO—O— whereby -L1-CO—O—R1 is formed,
- L3 is a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons,
- R3 is a linear or branched alkylene of 1, 2, 3, 4, 5 or 6 carbons, and
- R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons;
- or a pharmaceutically acceptable salt thereof.
7 more elements
Dependencies are inferred from the claim text.