US 9,849,452 B2Granted

Materials transport device for diagnostic and tissue engineering applications

AssigneeThe University of Georgia

InventorsKaren J. L. Burg, Suzanne Tabbaa

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Abstract

Devices that can transport biological materials are described. The devices incorporate capillary channeled fibers that can effectively transport living cells as well as other biological materials such as nutrients, growth factors, waste materials, etc. The devices can include a sorptive material at one end of the fibers that can improve transport of materials through the devices. The devices can differentially transport different cell types, particularly when the fibers are held in a vertical orientation. Diagnostic devices that incorporate the capillary channeled fibers are described that can be utilized to separate cell types from one another. Tissue engineering scaffolds that incorporate the capillary channeled fibers are described that can more efficiently transport materials into and out of the scaffolds.

Claims19

Dependent claims

A diagnostic device comprising:

a well that is configured for holding a fluid sample;
a capillary channeled fiber having a longitudinal axis along a length of the fiber an outer surface, and a non-circular cross section that is perpendicular to the longitudinal axis of the fiber, the capillary channeled fiber including a plurality of co-linear channels extending along the entire length of the fiber, each channel being open at the outer surface of the fiber, each channel being defined by two opposed walls, each wall that extending in a first direction that is along the length and parallel to the longitudinal axis of the fiber and each wall also extending in a second direction that is perpendicular to the longitudinal axis of the fiber with each wall forming a side wall of one channel and each wall forming a part of the exterior surface of the fiber;
and
a brace located in or above the well, the brace comprising a structure that secures the capillary channeled fiber in a vertical orientation with a first end of the fiber within the well.

1 more element

Dependencies are inferred from the claim text.

Facts

Application: 14/541,823Filed 14 Nov 2014 · us provisional application
Priority: 14 Nov 2013
Published: US 2015/0241320 A127 Aug 2015
Granted: 26 Dec 2017
Term ends: Not estimatedThe source records don’t support an estimate.

Classification21 codes

B01L 3/502
Containers for the purpose of retaining a material to be analysed, e.g. test tubes: with fluid transport, e.g. in multi-compartment structures
B01L 3/5025
With fluid transport, e.g. in multi-compartment structures: for parallel transport of multiple samples
B01L 3/5023
With fluid transport, e.g. in multi-compartment structures: with a sample being transported to, and subsequently stored in an absorbent for analysis
B01L 2200/025
Adapting objects or devices to another: align devices or objects to ensure defined positions relative to each other