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US 9,849,300 B2Granted
Transcranial magnetic stimulation (TMS) methods and apparatus
AssigneesChildren's Medical Center Corporation, Beth Israel Deaconess Medical Center, Inc.
InventorsAlvaro Pascual-Leone, Alexander Rotenberg, Iain Glass, Frances E. Jensen
Life of this patent
Estimating the term…
Abstract
Method and devices are provided for treating subjects with Transcranial Magnetic Stimulation (TMS). According to some approaches, the methods and devices are configured for the treatment of ongoing seizures. Other approaches relate to the use of TMS as an antiepileptogenic or for use in determining preferential placement of intracranial probes.
Claims21
A device for treating a seizure, the device comprising:
- a plurality of electromagnetic coils that receive power from a power source to produce a magnetic field;
- a controller that controls operation of the plurality of electromagnetic coils according to an operating protocol, wherein the operating protocol includes delivering an initial magnetic field having an intensity and a duration and delivering a plurality of subsequent magnetic fields, each of the subsequent magnetic fields having an intensity and a duration that is greater than the intensity and duration of previously delivered magnetic fields, respectively;
- a plurality of electrodes configured to receive a signal indicative of brain activity in a subject and to provide an electrical signal to the controller, wherein the controller is configured to start the operating protocol at a time after an indication of onset of a seizure, wherein the time is determined by analyzing the electrical signal to identify when to deliver the initial magnetic field relative to the subject's brain activity, and wherein the controller is further configured to stop the operating protocol by identifying, from the electrical signal, an indication of termination of a seizure;
- and
- an interface that includes the plurality of electrodes and the plurality of electromagnetic coils, the interface configured to position the plurality of electrodes to receive the signal and to position the plurality of electromagnetic coils to deliver the magnetic field to a subject's brain to treat the seizure.
2 more elements
A device for treating a seizure, the device comprising:
- a plurality of electromagnetic coils that receive power from a power source to produce a magnetic field;
- a controller configured to control operation of the plurality of electromagnetic coils according to an operating protocol and activate the operating protocol in response to detecting onset of a seizure, wherein the operating protocol includes delivering an initial magnetic field having an intensity and a duration and delivering a plurality of subsequent magnetic fields according to a predetermined sequence without manual operation until termination of the seizure is detected by the controller, each of the subsequent magnetic fields having an intensity and a duration that is greater than the intensity and duration of previously delivered magnetic fields, respectively;
- a plurality of electrodes configured to receive a signal indicative of brain activity in a subject and to provide an electrical signal to the controller, wherein the controller is configured to determine a time after detecting onset of the seizure by analyzing the electrical signal to identify at least one feature of the subject's brain activity and determining when to deliver the initial magnetic field to the subject based on the at least one feature, and wherein the controller is further configured to activate the operating protocol at the determined time;
- and
- an interface that includes the plurality of electrodes and the plurality of electromagnetic coils, the interface configured to position the plurality of electrodes to receive the signal and to position the plurality of electromagnetic coils to deliver the magnetic field to a subject's brain to treat the seizure.
2 more elements
Dependencies are inferred from the claim text.