Method to treat vascular dysfunction through enhanced vascular flow and hemodynamic activation of the autocrine and paracrine processes
OwnerJohn M. Oweninventor
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Abstract
A method and system for creating shear stress and endothelial mechanotransduction through neuromuscular stimulation of the muscle pump. Chronic application a minimum of 30 days triggers the autocrine and paracrine processes which elevates production of vasoactive substances including nitric oxide, prostacyclin, superoxide dismutase, thrombomodulin, glutathion, Krupple-like factor 2 and many others. Chronic application also promotes angiogenesis and development of collateral circulation. This is a cost-effective, non-invasive, drug-free therapy to treat vascular dysfunction and ameliorate or reverse its effects on cardiovascular health.
Claims18
A method for treating vascular dysfunction through neuromuscular stimulation and flow-mediated endothelial mechanotransduction, comprising the steps of:
- providing a controller for the generation of electrical waveforms;
- operably associating the controller to a plurality of treatment pads and a plurality of leads, the leads in electrical communication with the controller;
- coupling the plurality of treatment pads and treatment leads to both the upper and lower extremities of a human body;
- and
- initiating an electrical stimulation signal through the leads and into the tissue of the body, the controller regulating the electrical stimulation signal;
- wherein the electrical stimulation signal is configured to contract skeletal muscle on the body to induce endothelium mechanotransduction in a blood vessel, the endothelium mechanotransduction resulting from induced frictional drag between blood cells and an endothelial layer of the blood vessel, the endothelium mechanotransduction activating both paracrine and autocrine process;
- and
- wherein the electrical stimulation signal is regulated through the plurality of treatment pads and leads in a sequential manner with overlapping intervals of contractions from a distal end to a proximal end of each extremity.
Dependencies are inferred from the claim text.