Needle-like material and method for manufacturing needle-like material
AssigneeToppan Printing Co., Ltd.
InventorsHiroyuki Kato, Takako Yamamoto, Yoshikazu Taroura
Life of this patent
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Abstract
A needle-shaped structure includes a needle-shaped projection and a support substrate supporting the projection wherein the projection contains at least a chitosan and an organic acid, places a low burden on a living body and is able to keep the microscopic form after puncture into the skin.
Claims20
A method of producing a needle-shaped structure having a support substrate and a needle-shaped projection projected from the support substrate, the method comprising:
- preparing a liquid material comprising a chitosan material and an acid;
- applying the liquid material onto an intaglio plate having a needle-shaped recess;
- solidifying the liquid material applied onto the intaglio plate such that a solidified article made from the liquid material is obtained;
- separating the solidified article from the intaglio plate;
- and
- immersing separated solidified article in an aqueous alcohol solution which reduces the acid from the separated solidified article.
A method of producing a needle-shaped structure having a support substrate and a needle-shaped projection projected from the support substrate, the method comprising:
- preparing a liquid material comprising a chitosan material and an acid;
- applying the liquid material onto an intaglio plate having a needle-shaped recess;
- solidifying the liquid material applied onto the intaglio plate such that a solidified article made from the liquid material is obtained;
- separating the solidified article from the intaglio plate;
- and
- placing separated solidified article in a solution acetylating the chitosan material in the separated solidified article.
A method of producing a needle-shaped structure having a support substrate and a needle-shaped projection projected from the support substrate, the method comprising:
- preparing a liquid material comprising a chitosan material, a first acid, and a second acid;
- applying the liquid material onto an intaglio plate having a needle-shaped recess;
- solidifying the liquid material such that a solidified article made from the liquid material is obtained;
- separating the solidified article from the intaglio plate;
- and
- immersing separated solidified article in an aqueous alcohol solution,
- wherein the first acid is a tri- or higher valent carboxylic acid or a dicarboxylic acid having a number average molecular weight of not less than 110, and the second acid is a monocarboxylic acid or a dicarboxylic acid, having a number average molecular weight of less than 110.
Dependencies are inferred from the claim text.