Foam carrier for bone grafting

A method for accelerating bone repair in a patient in need of such treatment, the method comprising implanting at a target tissue site in need of replacement bone, an osteogenic composition comprising:

• polymeric beads comprising immediate release beads and sustained release beads for delivering an isolated osteoinductive agent, the isolated osteoinductive agent comprising a sterile growth factor at or near the target tissue site;
• the polymeric beads comprising the sterile growth factor, an excipient in an amount of from about 0.05 wt. % to about 85 wt. %, a viscosity enhancing agent, degradation/release modifiers and sterile preservative free material;
• and
• a porous foam comprising layers such that the immediate release beads and sustained release beads are disposed throughout the layers of the foam, the porous foam being biodegradable and containing a plurality of pores having a size between about 100 micrometers and about 350 micrometers at their widest points,
• wherein the growth factor comprises bone morphogenic protein in an amount from 1 to 2 mg per cubic centimeter of said osteogenic composition, and the foam has a density of between about 0.2 g/cm3 to about 1.1 g/cm3, and the porous foam comprises seeded bone cells or tissue, wherein the excipient is mPEG.