Antimicrobial wraps for medical implants
AssigneeBoard of Regents, The University of Texas System
InventorsJoel Rosenblatt, Issam Raad, Andrew P. Dennis
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Abstract
Biodegradable antimicrobial films are provided that are solid at room temperature and substantially liquefy in situ after implantation into a mammal, such as a human patient. Methods of using the films to cover a medical device, such as a breast implant, prior to insertion into a subject are also provided.
Claims33
A biodegradable covering for a medical implant, the covering comprising a highly plasticized gelatin and at least one drug to reduce infection or capsular contraction, wherein the plasticized gelatin has a melting temperature of less than 38° C., and wherein the plasticized gelatin consists essentially of gelatin and from greater than 40% to about 60% plasticizer.
A biodegradable covering for a medical implant, the covering comprising a highly plasticized gelatin and at least one drug to reduce infection or capsular contraction, wherein the plasticized gelatin has a melting temperature of less than 38° C., wherein at least a portion of a surface of the covering has been treated with a gluconic acid solution.
A biodegradable covering for a medical implant, the covering comprising a highly plasticized gelatin and at least one drug to reduce infection or capsular contraction, wherein the plasticized gelatin has a melting temperature of less than 38° C.;
- wherein the covering is sufficient in size or shaped to cover a breast implant;
- wherein the covering is shaped as a film, a wrap, a pouch or a bag;
- and wherein the covering is a pouch or a bag;
- wherein the covering has a central region and a plurality of lateral appendages, or the covering is substantially star-shaped.
A biodegradable covering for a medical implant, the covering comprising a highly plasticized gelatin and at least one drug to reduce infection or capsular contraction, wherein the plasticized gelatin has a melting temperature of less than 38° C.;
- wherein the covering comprises minocycline, rifampin, and mercaptoethane sulfonate;
- and wherein the covering further comprises glyceryl trinitrate (GTN), a monoglyceride, or a fatty acid.
A biodegradable covering for a medical implant, the covering comprising a highly plasticized gelatin and at least one drug to reduce infection or capsular contraction, wherein the plasticized gelatin has a melting temperature of less than 38° C.;
- wherein at least a portion of the covering has been exposed to crosslinking;
- and wherein the covering comprises regions that have been exposed to crosslinking and regions that have not been exposed to crosslinking.
A biodegradable covering for a medical implant, the covering comprising a highly plasticized gelatin and at least one drug to reduce infection or capsular contraction, wherein the plasticized gelatin has a melting temperature of less than 38° C.;
- wherein the covering comprises multiple layers;
- and wherein the covering comprises a first layer comprising a partially crosslinked plasticized gelatin and a second layer comprising a plasticized gelatin that has not been crosslinked, wherein the second layer comprises the drug.
A biodegradable covering for a medical implant, the covering comprising a highly plasticized gelatin and at least one drug to reduce infection or capsular contraction, wherein the plasticized gelatin has a melting temperature of less than 38° C.;
- wherein the highly plasticized gelatin is comprised on an adhesive backing.
Dependencies are inferred from the claim text.