Porous orthopedic materials coated with demineralized bone matrix
AssigneeBiomet Manufacturing, LLC
InventorsJennifer Woodell-May, Karen Troxel
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Abstract
A biomaterial including a porous biocompatible structure having interconnected pores, wherein the pores have interior walls and are interconnected by passageways, the interior walls and passageways being coated with an osteoinductive aqueous demineralized bone extract solution, the aqueous demineralized bone extract solution including growth factors, proteins, a demineralized bone matrix and at least one of a weak acid and a guanidine hydrochloride, wherein the demineralized bone matrix is present per 100 g of the solution in an amount of from about 2 g to about 10 g.
Claims20
A biomaterial comprising:
- a porous biocompatible structure comprising interconnected pores, wherein the pores comprise interior walls and are interconnected by passageways;
- an aqueous demineralized bone extract coating comprising growth factors, proteins or a combination thereof, wherein the aqueous demineralized bone extract coating is formed by dissolving soluble demineralized bone matrix in an aqueous solution comprising at least one of a weak acid or guanidine hydrochloride;
- and
- a demineralized bone gelatin coating comprising a demineralized bone matrix gelatin comprising demineralized bone matrix suspended in an aqueous saline solution, wherein the aqueous saline solution is heated to dissolve the demineralized bone matrix to form the demineralized bone matrix gelatin;
- wherein the demineralized bone extract coating and the demineralized bone gelatin coating cover the interior walls and passageways.
An orthopedic implant comprising:
- a porous biocompatible structure comprising interconnected pores, wherein the pores comprise interior walls and are interconnected by passageways and wherein the pores have an average diameter of from about 200 microns to about 500 microns;
- an aqueous demineralized bone extract coating comprising growth factors, proteins or a combination thereof, wherein the aqueous demineralized bone extract coating is formed by dissolving soluble demineralized bone matrix in an aqueous solution comprising at least one of a weak acid or guanidine hydrochloride;
- and
- a demineralized bone gelatin coating comprising demineralized bone matrix suspended in an aqueous saline solution, wherein the aqueous saline solution is heated to dissolve the demineralized bone matrix to form the demineralized bone matrix gelatin;
- wherein the demineralized bone extract coating and the demineralized bone gelatin coating covers the interior walls and passageways, wherein the bone extract coating is dried on the interior walls and passageways.
Dependencies are inferred from the claim text.