Implants for inducing soft and hard tissue integration

A biocompatible implant for improved osseointegration and soft tissue attachment when implanted into a mammalian body, comprising a combination of:

• one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof, the one or more metal(s), metal alloy(s), metal oxide(s) or a combination thereof having at least one surface, and
• a coating containing a methoxytryptophol or flavonoid compound either directly attached to the at least one surface by a covalent bond, or attached through an optional linker;
• wherein the methoxytryptophol or flavonoid compound is selected from the group of flavonoids, methoxytryptophols, an ester thereof, a pharmaceutically acceptable salt thereof, and a combination thereof,
• wherein the methoxytryptophol or flavonoid compound is/are coated to at least a part of the surface of the metal, metal alloy or metal oxide of said biocompatible implant,
• wherein the methoxytryptophol or flavonoid compound is covalently attached to the surface of the metal, metal alloy or metal oxide so that either
• the methoxytryptophol or flavonoid compound is directly attached to the one or more of the metal, metal alloy or metal oxide forming a covalent bond therewith, or
• the methoxytryptophol or flavonoid compound is bound to the surface of the one or more of the metal, metal alloy or metal oxide through the optional linker forming a covalent bond between the methoxytryptophol or flavonoid compound and the linker and between the linker and the one or more of the metal, metal alloy or metal oxide;
• and
• wherein the linker is selected from the group of one or more of anhydrides, alcohols, acids, amines, epoxides, isocyanates, silanes, thiol, alkyl, aryl, and halogenated groups;
• and
• whereby the combination is configured to provide improved osseointegration and soft tissue attachment when implanted into a mammalian body;
• and
• wherein further biomolecules are present on the surface of the metal, metal alloy or metal oxide of the implant, said biomolecules being selected from natural biomolecules, synthetic biomolecules, and recombinant biomolecules, cell attachment factors, biopolymers, blood proteins, enzymes, extracellular matrix proteins and biomolecules, growth factors and hormones, nucleic acids, receptors, synthetic biomolecules, vitamins, drugs, biphosphonates, biologically active ions, and marker biomolecules.