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US 9,849,201 B2Granted
Homing agents
AssigneeWashington University
InventorsGregory M Lanza, Samuel A. Achilefu, Grace Hufang Cui
Life of this patent
Estimating the term…
Abstract
The present disclosure provides peptide constructs for diagnostic imaging and therapeutic applications, using pegylated peptides which exhibit specific binding for a target molecule of interest, such as a biomarker of a disease or disorder.
Claims17
A p-armed multimer, each arm of the multimer comprising:
- a polymer comprising n PEG monomers, wherein n is at least 2;
- a linker comprising His-His-Glu;
- and
- a homing molecule selected from the group consisting of an antibody, an aptamer, and a peptide, wherein the homing molecule binds a biomarker of thrombosis,
- wherein the homing molecule is linked to the C-terminus of the linker, and the polymer is linked via an amino acid side chain of the linker;
- and
- wherein p is at least 3, and each arm of the multimer is bound to the other arms of the multimer via an end of the polymer not attached to the linker;
- wherein the p-armed multimer further comprises at least one diagnostic and/or therapeutic agent attached to an N-terminus of the linker of that arm, wherein the at least one diagnostic agent or therapeutic agent is a radioisotope of technetium or a radioisotope of rhenium.
5 more elements
A p-armed multimer, each arm of the multimer comprising:
- a polymer comprising n PEG monomers, wherein n is at least 2;
- a linker comprising His-His-Glu;
- and
- a homing molecule that is an antibody, wherein the homing molecule binds a target molecule;
- wherein the homing molecule is linked to the C-terminus of the linker, and the polymer is linked via an amino acid side chain of the linker;
- and
- wherein p is at least 3, and each arm of the multimer is bound to the other arms of the multimer via an end of the polymer not attached to the linker;
- wherein the p-armed multimer further comprises at least one diagnostic and/or therapeutic agent attached to an N-terminus of the linker of that arm, wherein the at least one diagnostic agent or therapeutic agent is a radioisotope of technetium or a radioisotope of rhenium.
5 more elements
A p-armed multimer, each arm of the multimer comprising:
- a polymer comprising n PEG monomers, wherein n is at least 2;
- a linker comprising His-His-Glu;
- and
- a homing molecule comprising SEQ ID NO:
- 1;
- wherein the homing molecule is linked to the C-terminus of the linker, and the polymer is linked via an amino acid side chain of the linker;
- and
- wherein p is at least 3, and each arm of the multimer is bound to the other arms of the multimer via an end of the polymer not attached to the linker;
- wherein the p-armed multimer further comprises at least one diagnostic and/or therapeutic agent attached to an N-terminus of the linker of that arm, wherein the at least one diagnostic agent or therapeutic agent is a radioisotope of technetium or a radioisotope of rhenium.
6 more elements
Dependencies are inferred from the claim text.