Back to results
US 9,849,200 B2Granted
Strontium phosphate microparticle for radiological imaging and therapy
AssigneeMo-Sci Corporation
InventorsDelbert E. Day, Yiyong He
Life of this patent
Estimating the term…
Abstract
This invention relates to strontium-phosphate microparticles that incorporate radioisotopes for radiation therapy and imaging.
Claims19
A radio microparticle comprising:
- crystalline strontium phosphate and at least one radioisotope suitable for radio imaging and/or radiotherapy bonded or adsorbed to the surface thereof, wherein the microparticle has a surface area of greater than 90 square meters per gram.
A process for the preparation of a radio microparticle, comprising:
- (i) reacting a strontium-containing borate glass microparticle with a phosphate solution such as to convert at least a portion of the strontium-containing borate glass to crystalline strontium phosphate;
- and
- (ii) bonding or adsorbing at least one radioisotope suitable for radio imaging and/or radiotherapy to said strontium phosphate microparticle by bringing the microparticle into contact with a solution containing the radioisotope.
A method of administering a radio microparticle to a patient in need thereof, comprising:
- locally delivering the radio microparticle in a physiologically acceptable carrier to a tissue target or organ of the patient,
- wherein the radio microparticle comprises crystalline strontium phosphate and at least one radioisotope suitable for radio imaging and/or radiotherapy bonded or adsorbed to the surface thereof,
- wherein the microparticle has a surface area of greater than 90 square meters per gram.
A method of obtaining a radiologic image of a tissue or organ of a patient, comprising:
- administering a radio microparticle in a physiologically acceptable carrier to a tissue target or organ of the patient, and
- obtaining the radiologic image of the tissue or organ of the patient;
- wherein the radio microparticle comprises crystalline strontium phosphate and at least one radioisotope suitable for radio imaging bonded or adsorbed to the surface thereof,
- wherein the microparticle has a surface area of greater than 90 square meters per gram.
1 more element
Dependencies are inferred from the claim text.