Compositions and methods for imaging and treatment
AssigneeNew York University
InventorsAli Trabolsi, Farah Benyettou
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Abstract
Provided are compositions and methods for transport, monitoring the transport, and controlled release of active agents. The compositions comprise surface functionalized iron oxide nanoparticles. The iron oxide nanoparticles are surface functionalized with cucurbitril[7] macrocycles. The cavity formed by the CB[7] macrocycles can be used for storage and transport of active agents. The active agents may be imaging agents or may be therapeutic agents which can be released by applying an alternating magnetic field at desired locations.
Claims19
An iron oxide nanoparticle having a diameter from 5 nm to 15 nm and having adsorbed on the surface thereof a plurality of cucurbituril[7] (CB[7]) molecules, wherein the CB[7] molecules are adsorbed on the iron oxide nanoparticle surface via carbonyl groups of the CB[7] molecules and wherein each CB[7] molecule encloses a hydrophobic cavity.
Dependencies are inferred from the claim text.