Targeted delivery of antimicrobial agents
AssigneeGeorge Mason Research Foundation, Inc.
InventorsBarney Bishop, Monique van Hoek, Keith M. Davies
Life of this patent
Estimating the term…
Abstract
A cationic antimicrobial peptide (CAMP) conjugate is disclosed. The CAMP conjugate may be made by identifying a suitable carrier peptide; identifying a suitable antimicrobial agent; creating a conjugate by conjugating the peptide with the antimicrobial agent; and evaluating and refining the conjugate. The peptide may be short peptide based on the sequence of a CAMP, such as human β-defensin-3. The peptide can be directly connected to the antimicrobial agent or through a linker segment. The antimicrobial agent may be connected to the peptide or the linker segment through stable or cleavable bonding. The peptide may carry and facilitate the delivery of the conjugated antimicrobial agent to a microbe.
Claims11
A method for delivering an antimicrobial agent to a microbe, comprising contacting the microbe with a cationic antimicrobial peptide (CAMP) conjugated to the antimicrobial agent, wherein the CAMP comprises the amino acid sequence RGRRSSRRKK (SEQ ID NO:3), and wherein the CAMP is connected to the antimicrobial agent directly or through a linker segment, the antimicrobial agent being connected to the CAMP or the linker segment through a stable or cleavable bond.
Dependencies are inferred from the claim text.