Growth hormone polypeptides and methods of making and using same
AssigneeAmunix Operating Inc.
InventorsVolker Schellenberger, Joshua Silverman, Willem P. Stemmer, Chia-wei Wang, Nathan Geething, Jeffrey L. Cleland, Benjamin Spink
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Abstract
The present invention relates to compositions comprising growth hormone linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of growth hormone-related diseases, disorders, and conditions.
Claims24
An isolated fusion protein, comprising a growth hormone (GH) that is at least 90% identical to the amino acid sequence of SEQ ID NO:1, wherein said growth hormone is linked to an extended recombinant polypeptide (XTEN) of at least 100 to about 3000 amino acids residues, wherein the XTEN is characterized in that:
- (a) at least 80% the XTEN sequence consist of non-overlapping sequence motifs, wherein:
- (i) each sequence motif has 12 to 36 amino acid residues, and
- (ii) each motif consist of 4 to 6 types of amino acids selected from glycine (G), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P);
- and
- (b) the sum of glycine (G), alanine (A), serine (S), threonine (T), glutamate (E) and proline (P) residues constitutes more than 90% of the total amino acid residues of the XTEN sequence;
- and
- wherein the XTEN comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 29-58.
Dependencies are inferred from the claim text.