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US 9,849,186 B2Granted
Triblock copolymer and use therefor
AssigneeUniversity of Tsukuba
InventorsYukio Nagasaki, Min Ley Pua, Pennapa Chonpathompikunlert, Toru Yoshitomi
Life of this patent
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Abstract
Provided is a triblock copolymer represented by General Formula (I): CNR-PEG-CNR (1) or a polycation thereof, wherein each CNR is independently a polymer segment having a repeating unit containing as part of a pendant group a cyclic nitroxide radical that binds to the polymer main chain via a linking group having at least one imino group or ether bond, and PEG is a segment containing poly(ethylene glycol).
Claims9
A composition comprising:
- a polyion complex comprising a polyanion selected from the group consisting of poly(acrylic acid), poly(methacrylic acid), poly(sulfonic acid), DNA, RNA and anionic proteins, and a triblock copolymer or salt thereof of following formula:
- wherein each L1 is independently selected from the group consisting of a single bond, —S—(CH2)c—, —S—(CH2)cCO—, —(CH2)cS— and —CO(CH2)cS—, in which c is an integer from 1 to 5;
- each L2 is independently —C1-6 alkylene-NH—(C1-6 alkylene)q-, in which q is the integer 0 or 1;
- and at least 50% of the total number n of R in the formula independently represent residues of cyclic nitroxide radical compounds selected from the group consisting of 2,2,6,6-tetramethylpiperidine-1-oxyl-4-yl, 2,2,5,5-tetramethylpyrrolidine-1-oxyl-3-yl, 2,2,5,5-tetramethylpyrroline-1-oxyl-3-yl, 2,4,4-trimethyl-1,3-oxyazolidine-3-oxyl-2-yl, 2,4,4-trimethyl-1,3-thiazolidine-3-oxyl-2-yl and 2,4,4-trimethyl-imidozolidine-3-oxyl-2-yl, with other R if any representing hydrogen atoms, halogen atoms or hydroxy groups, and m is an integer from 20 to 5,000 while each n is independently an integer from 3 to 1,000,
- wherein the polyion complex is in the form of a polyion complex micelle in Na2HPO4 buffer (0.1M) at pH 6.28,
- wherein said composition forms a gel when injected into a living body and said gel is retained in a specific area of the body selected from the group consisting of a periodontal pocket, a cancer lesion and a site affected by arthritis;
- and wherein the composition further provides at least one property selected from the group consisting of suppressing inflammation, scavenging active oxygen, and regulating fluidity.
4 more elements
Dependencies are inferred from the claim text.