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US 9,849,177 B2Granted
Process for purifying recombinant plasmodium falciparum circumsporozoite protein
AssigneePfenex Inc.
InventorsJeffrey Allen, Ryan Haverstock
Life of this patent
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Abstract
The present invention relates to processes for purifying high-quality recombinant Plasmodium falciparum circumsporozoite protein at high yields.
Claims14
A stable liquid formulation of recombinant P. falciparum circumsporozoite protein (rCSP), the rCSP comprising the most N-terminal cysteine, wherein the most N-terminal cysteine corresponds to the cysteine at position 25 as set forth in SEQ ID NO:
- 1, the formulation comprising about 1 to about 50 mg/ml rCSP in a formulation buffer comprising about 0.5 to about 1.5 mM monothioglycerol (MTG) and about 10% to about 20% arginine.
A stable liquid formulation of rCSP, the rCSP comprising the most N-terminal cysteine, wherein the most N-terminal cysteine corresponds to the cysteine at position 25 as set forth in SEQ ID NO:
- 1, the formulation comprising about 1 to about 50 mg/ml rCSP, in a formulation buffer comprising about 0.5 to about 1.5 mM monothioglycerol (MTG) and about 1% to about 20% arginine.
Dependencies are inferred from the claim text.