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US 9,849,170 B2Granted
Microneedle coating composition and microneedle device
AssigneesHisamitsu Pharmaceutical Co., Inc., The Chemo-Sero-Therapeutic Research Institute
InventorsKazuya Machida, Seiji Tokumoto, Kazuyoshi Kaminaka, Yuji Ishikawa
Life of this patent
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Abstract
Disclosed is a microneedle coating composition comprising a Japanese encephalitis vaccine antigen, a basic amino acid, and an acid, wherein the mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents the valence of the acid.
Claims10
A microneedle coating composition comprising:
- a Japanese encephalitis vaccine antigen;
- a basic amino acid in a concentration of 20% w/w or more based on the total mass of the microneedle coating composition;
- and
- an acid in a concentration of 5% to 50% w/w based on the total mass of the microneedle coating composition, wherein the acid is at least one acid selected from the group consisting of phosphoric acid, lactic acid, benzoic acid, maleic acid, citric acid, tartaric acid, succinic acid, ascorbic acid and aspartic acid, wherein
- a mole number of the acid for one mole of the basic amino acid is larger than 1/(N+1) and less than 2, where N represents a valence of the acid.
2 more elements
Dependencies are inferred from the claim text.