Oligomer-specific amyloid beta epitope and antibodies
AssigneeThe University of British Columbia
InventorNeil R. Cashman
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Abstract
A novel constrained peptide epitope derived from Aβ, related antibody compositions and methods of use. An isolated antibody that specifically binds to a cyclic peptide comprising the conformational epitope corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric Aβ is described. An antigenic peptide comprising an epitope having a constrained cyclic configuration, corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric Aβ is also described. Methods of treating, preventing, and diagnosing Alzheimer's disease are also described.
Claims12
An antigenic peptide comprising a conformational epitope having a constrained cyclic configuration, wherein the conformational epitope has an amino acid sequence of at least SNK corresponding to a solvent-exposed, antibody accessible knuckle region of oligomeric Aβ, and wherein the K (Lysine) is solvent-exposed.
Dependencies are inferred from the claim text.