Treatment with factor VII-albumin fusion protein
AssigneeAlbumedix A/S
InventorsDavid J. Ballance, Darrell Sleep
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Abstract
The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
Claims16
A method of treating a patient in need of a Factor VII polypeptide, comprising the step of administering an effective amount of an albumin fusion protein comprising a Factor VII polypeptide fused to an albumin polypeptide, wherein the albumin polypeptide has the ability to prolong the serum half-life of the fused Factor VII polypeptide compared to the unfused Factor VII polypeptide, wherein the fused Factor VII polypeptide has Factor VII coagulant activity, wherein the Factor VII polypeptide is fused at the N-terminus of the albumin polypeptide, and wherein the albumin polypeptide is selected from:
- a) a full-length albumin;
- b) a mature albumin;
- c) a fragment of albumin;
- d) a polypeptide consisting of an amino acid sequence at least 95% identical to SEQ ID NO:18;
- and
- e) amino acids 1 to 387 of SEQ ID NO:18;
- and wherein the Factor VII polypeptide is selected from:
- i) a full-length Factor VII;
- ii) an activated Factor VII (Factor VIIa);
- iii) a fragment of Factor VII having a deletion that consists of 1-50 amino acid residues compared to mature Factor VII;
- iv) a polypeptide consisting of an amino acid sequence at least 90% identical to the sequence of amino acids 39 (Ala) to 444 (Pro) of SEQ ID NO:
- 47;
- and
- a mature Factor VII.
Dependencies are inferred from the claim text.