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AssigneeOmniActive Health Technologies (Canada) Limited
InventorsJayant Deshpande, Khadija Ghanam, Stephen Ewart, Vijaya Juturu
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A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25,26-oxidofriedelane-1,3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.
A Salacia composition, comprising at least 12% polyphenols, at least 2% mangiferin, and at least 1% 25,26-oxidofriedelane-1,3-dione by weight of the composition, wherein a daily amount of the 25,26-oxidofriedelane-1,3-dione is at least 5 mg/kg, and the composition exhibits activity including reducing appetite, activating Hormone Sensitive Lipase, and/or maintaining a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme, wherein the compounds are obtained from Salacia plant parts as an extract by a first extraction with a first solvent at 60° C.-65° C. for three hours, then filtration, and by a second extraction with a second solvent at 60° C.-65° C. for one hour, then filtration.
A method of reducing appetite, activating hormone sensitive lipase, and/or inhibiting HMG-CoA reductase enzyme, the method comprises administering an effective amount of a Salacia composition to a subject in need thereof, the composition comprising at least 12% polyphenols, at least 2% mangiferin, and at least 1% 25,26-oxidofriedelane-1,3-dione by weight of the composition, wherein a daily amount of the 25,26-oxidofriedelane-1,3-dione is at least 5 mg/kg and wherein the compounds are extracted from Salacia plant parts, and obtained by a first extraction with a first solvent at 60° C.-65° C. for three hours, then filtration, and by a second extraction with a second solvent at 60° C.-65° C. for one hour, then filtration.
A process for preparation of novel Salacia composition, comprising at least 12% polyphenols, at least 2% mangiferin, and at least 1% 25,26-oxidofriedelane-1,3-dione by weight of the composition, the compounds are extracted from Salacia plant parts, wherein the 25,26-oxidofriedelane-1,3-dione is in a daily amount of at least 5 mg/kg, and the composition reduces appetite, activates Hormone Sensitive Lipase, and/or manages healthy lipid profile, the process comprising:
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