Methods for accelerated return of skin integrity and for the treatment of impetigo
AssigneeFoamix Pharmaceuticals Ltd.
InventorsDov Tamarkin, Elana Gazal, Rita Keynan, Meir Eini, David Schuz
Life of this patent
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Abstract
Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelerating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.
Claims16
A method of treating or alleviating impetigo comprising topically administering an effective amount of a tetracycline antibiotic foam to a target area on a mammal in need thereof, wherein the target area comprises an area of skin or mucosa, and wherein the tetracycline antibiotic foam is produced from a foamable composition comprising:
- (a) 60% to 90% by weight of at least one hydrophobic oil;
- (b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, a paraffin wax, a plant wax, an animal wax, a polyethylene wax, and a mixture of two or more thereof;
- (c) at least one solid fatty alcohol having a carbon chain length of 14 to 22 carbons;
- (d) optionally at least one solid fatty acid having a carbon chain length of 12 to 28 carbons;
- (e) a tetracycline antibiotic selected from the group consisting of tetracycline, oxytetracycline, demeclocycline, doxycycline, lymecycline, meclocycline, methacycline, minocycline, rolitetracycline, chlorotetracycline, tigecycline, and a mixture of two or more thereof;
- and
- (f) a liquefied or compressed gas propellant;
- and
- wherein the foamable composition does not comprise a surfactant.
Dependencies are inferred from the claim text.