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AssigneePontificia Universidad Catolica De Chile
InventorsAlexis M. Kalergis, Andres A. Herrada
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The present invention relates to the use of spironolactone for the preparation of a pharmaceutical composition intended for preventing and/or treating multiple sclerosis. Alternatively, the invention relates to the use of spironolactone directly in T-lymphocytes or dendritic cells obtained from a blood sample taken from a patient and then injected back into the circulation. Therefore, the present invention relates to the use of a composition comprising spironolactone that can be used in the treatment of multiple sclerosis, which covers the administration of spironolactone directly or lymphocytes pre-treated with spironolactone, or dendritic cells to individuals requiring such treatment. Spironolactone is an orally administered drug that is less expensive than many of the treatments available for MS and, furthermore, has the advantage of being a known compound already used in humans for extended periods and therefore the adverse effects thereof have been described in clinical studies.
A method of treating multiple sclerosis, comprising administering to a patient in need thereof a pharmaceutical composition comprising a therapeutically effective amount of spironolactone or a polymorph, hydrate, or solvate thereof as the sole active ingredient and a pharmaceutically acceptable excipient, wherein the composition inhibits activation of T-lymphocytes in the patient, and wherein the method does not include administration of aldosterone to the patient.
A method of treating multiple sclerosis, comprising obtaining T-cells and dendritic cells from peripheral blood of a patient suffering from multiple sclerosis, treating the T-cells and dendritic cells with a pharmaceutical composition comprising 2 to 10 μg/ml of spironolactone or a polymorph, hydrate, or solvate thereof as the sole active ingredient and a pharmaceutically acceptable excipient, and intravenously administering the treated T-cells and dendritic cells to the patient.
Dependencies are inferred from the claim text.