1,4-benzodiazepone-2,5-diones and related compounds with therapeutic properties

A method of treating a fibrosis, comprising administering to a subject in need thereof a therapeutically effective amount of a compound of the formula:

• or a pharmaceutically acceptable salt thereof;
• wherein R2 is selected from the group consisting of H, alkyl, and substituted alkyl;
• wherein R3 is selected from the group consisting of H;
• alkyl;
• and OH;
• wherein R4 is N;
• wherein R5 is selected from the group consisting of H, alkyl, substituted alkyl, mono-substituted aryl, di-substituted aryl, and tri-substituted aryl;
• wherein R6 is N;
• wherein R7, R8, R9, and R10 are independently absent or are selected from the group consisting of —H, halogen, —CF3,
• —OH, fluoroalkyl, —SO2R28, —SO2N(R7′)2, —OR7′, —N(R7′)2, —CON(R7′)2, —NHCOR7′, —NHSO2R7′, alkyl, mono-substituted alkyl, di-substituted alkyl, tri-substituted alkyl;
• wherein R7′ is selected from the group consisting of halogen, H, alkyl, mono-substituted alkyl, di-substituted alkyl, tri-substituted alkyl, aryl, mono-substituted aryl, di-substituted aryl, tri-substituted aryl, cycloaliphatic, mono-substituted cycloaliphatic, di-substituted cycloaliphatic, and tri-substituted cycloaliphatic;
• wherein R15, R16, R17, and R18 are C;
• wherein R25, R26, R27, and R28 are independently selected from the group consisting of hydrogen, alkyl,
• wherein no more than three of R25, R26, R27, and R28 can be hydrogen;
• wherein the stereochemical configuration at a stereocenter in the compound is R, S, or a mixture thereof;
• wherein each substituted alkyl, substituted cycloaliphatic, or substituted aryl independently has at least one of the hydrogen atoms replaced by a halogen, an amino, a hydroxy, a nitro, a lower aliphatic, an aryl, or a cycloaliphatic;
• and
• wherein the fibrosis is located in one or more of the subject's hands, intestines, joints, lungs, liver, heart, and skin.